![]() ![]() Although the skin has the ability to heal itself, severe burns require a variety of interventions, such as healing drugs, debridement, and skin grafts. The primary goal of burn treatment is effective wound management, which largely determines the survival and prognosis of patients with severe burns. After effective and timely treatment, many patients can retain a considerable quality of life. The World Health Organization indicated that nearly 300,000 deaths occur annually, worldwide, from burns, but most of them not caused by fatal burns. In general, stem cells can potentially become a novel therapy candidate for burn wounds.Įven at current medical levels, burn remains a serious public health problem with high morbidity and mortality worldwide. These findings also demonstrate the need for considering variations in future clinical studies using stem cells to treat a burn wound in order to maximize the effectiveness. Meta-analysis showed that stem cell therapy exerts a healing function for burn wounds, mainly through angiogenesis and anti-inflammatory actions. Furthermore, stem cell therapy seemed to exert more beneficial effects on burn wounds with second-degree (SMD 7.53, 95% CI 3.11 to 11.95) compared with third-degree (SMD 2.65, 95% CI 1.31 to 4.00). Subgroup analyses indicated that hair follicle stem cells seemed to exert more beneficial effects on animals with burn wounds (SMD 7.53, 95% CI 3.11 to 11.95) compared with other stem cells. ![]() The overall meta-analysis showed that stem cell therapy significantly improved burn healing rate (SMD 3.06, 95% CI 1.98 to 4.14), irrespective of transplant type, burn area, and treatment method in the control group. RevMan 5.3 was used for all data analysis. No language or time restrictions were enforced. In addition, a manual search of references of studies was performed to obtain potential studies. Twenty-two studies with 595 animals were identified by searching PubMed, EMBASE, Web of Science, and Cochrane Library databases from inception to. The systematic review was performed for these preclinical studies to assess the efficacy and possible mechanisms of stem cells in treating burn wounds. Stem cell therapy has a bright prospect in many preclinical studies of burn wounds. Although there are various treatment options available, there is no consensus on the best treatment for severe burns as of yet. Burns remain a serious public health problem with high morbidity and mortality rates worldwide. ![]()
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